资源类型

期刊论文 270

年份

2024 2

2023 27

2022 27

2021 22

2020 16

2019 16

2018 12

2017 9

2016 12

2015 12

2014 12

2013 11

2012 10

2011 9

2010 21

2009 4

2008 7

2007 11

2006 5

2005 5

展开 ︾

关键词

风险分析 9

风险管理 7

风险评估 5

安全风险 3

风险 3

风险控制 3

南京长江隧道 2

危险性分析 2

地震 2

安全设计 2

建筑火灾 2

抗生素 2

风险决策 2

1)模型 1

2型糖尿病 1

ANP 1

COVID-19 1

EMD距离 1

F-N图 1

展开 ︾

检索范围：

排序： 展示方式：

Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem celltransplantation: PAH risk score

《医学前沿（英文）》 2022年 第16卷 第6期   页码 957-968 doi: 10.1007/s11684-021-0910-1

摘要： Skin and soft tissue infections (SSTIs) refer to infections involving the skin, subcutaneous tissue, fascia, and muscle. In transplant populations with hematological malignancies, an immunocompromised status and the routine use of immunosuppressants increase the risk of SSTIs greatly. However, to date, the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation (HSCT) patients remain unclear. This study included 228 patients (3.67%) who developed SSTIs within 180 days after allogeneic HSCT from January 2004 to December 2019 in Peking University People’s Hospital. The overall annual survival rate was 71.5%. We compared the differences between survivors and non-survivors a year after transplant and found that primary platelet graft failure (PPGF), comorbidities of acute kidney injury (AKI), and hospital-acquired pneumonia (HAP) were independent risk factors for death in the study population. A PPGF–AKI–HAP risk stratification system was established with a mortality risk score of 1×PPGF+1×AKI+1×HAP. The areas under the curves of internal and external validation were 0.833 (95% CI 0.760–0.906) and 0.826 (95% CI 0.715–0.937), respectively. The calibration plot revealed the high consistency of the estimated risks, and decision curve analysis showed considerable net benefits for patients.

关键词： skin and soft tissue infections     hematopoietic stem cell transplantation     risk stratification system     mortality    

HTML PDF 收藏

Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing

Ling Wang, Ying Wang, Jiong Hu, Yuqian Sun, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang

《医学前沿（英文）》 2019年 第13卷 第3期   页码 365-377 doi: 10.1007/s11684-018-0641-0

摘要： Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies. In this study, we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset ( =3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression, which included the following variables: male patients, induction chemotherapy for newly diagnosed or relapsed disease, neutropenia, neutropenia longer than 10 days, hypoalbuminemia, central-venous catheter, and history of IFD. The patients were classified into three groups, which had low (0–10, ~1.2%), intermediate (11–15, 6.4%), and high risk (>15, 17.5%) of IFD. In the validation set ( =1389), the IFD incidences of the groups were ~1.4%, 5.0%, and 21.4%. In addition, we demonstrated that anti-fungal prophylaxis offered no benefits in low-risk patients, whereas benefits were documented in intermediate (2.1% vs. 6.6%, =0.007) and high-risk patients (8.4% vs. 23.3%, =0.007). To make the risk score applicable for clinical settings, a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established, and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD. In conclusion, an objective, weighted risk score for IFD was developed, and it may be useful in guiding antifungal prophylaxis.

关键词： invasive fungal diseases     hematological malignancies     chemotherapy     risk score     prophylaxis    

HTML PDF 收藏

study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

《医学前沿（英文）》 2021年 第15卷 第4期   页码 585-593 doi: 10.1007/s11684-020-0817-2

摘要： Stevens--Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe diseases. This study aimed to validate the predictive ability of risk models in patients with SJS/TEN and propose possible refinement in China. Patients in the Department of Dermatology of Huashan Hospital from January 2008 to January 2019 were included. Results showed that the severity-of-illness score for TEN (SCORTEN) had a good discrimination (area under the receiver operating characteristic curve (AUC), 0.78), and it was superior to auxiliary score (AS) and ABCD-10, which indicates age, bicarbonate level, cancer, dialysis, and 10% involved body surface area (AUC, 0.69 and 0.68, respectively). The calibration of SCORTEN (Hosmer–Lemeshow goodness-of-fit test, = 0.69) was also better than that of AS ( = 0.25) and ABCD-10 ( = 0.55). SCORTEN and ABCD-10 were similar (Brier score (BS), 0.04 and 0.04) in terms of accuracy of predictions. In addition, the imaging appearance of pulmonary consolidation on computed tomography was associated with high mortality. Refined models were formed using the variables and this imaging appearance. The refined AS and ABCD-10 models were similar in discrimination compared with the original SCORTEN (0.74 vs. 0.78, = 0.23; 0.74 vs. 0.78, = 0.30, respectively). Therefore, SCORTEN showed good discrimination performance, calibration, and accuracy, and refined AS or ABCD-10 model may be an option when SCORTEN variables are not available.

关键词： Stevens–Johnson syndrome     toxic epidermal necrolysis     auxiliary score     ABCD-10     pulmonary consolidation    

HTML PDF 收藏

rice genotypes in stress environments: fine-tuning a selection method using production and resilience score

《农业科学与工程前沿（英文）》 doi: 10.15302/J-FASE-2023521

摘要：

● Score index methods readily discriminate genotypes adapted to a target environment.

关键词： Aerobic rice     breeding selection     drought resilience     production capacity index     resilience capacity index     stress score index     upland    

HTML PDF 收藏

COVID-19住院患者预后风险评分系统的开发和验证——一项多中心回顾性研究 Article

袁烨, 孙川, 唐秀川, 程骋, Laurent Mombaerts, 王茂霖, 胡涛, 孙晨宇, 郭裕祺, 李秀婷, 徐卉, 任彤鑫, 肖阳, 肖亚茹, 朱红玲, 吴鸿汉, 李克之, 陈楚明, 刘映霞, 梁智超, 曹治国, 张海涛, Ioannis Ch. Paschaldis, 刘泉影, Jorge Goncalves, 钟强, 严丽

《工程（英文）》 2022年 第8卷 第1期   页码 116-121 doi: 10.1016/j.eng.2020.10.013

摘要：

新冠病毒肺炎（COVID-19）已成为世界范围内的流行疾病。COVID-19 住院患者的死亡率较高，促使研究人员研发方便实用的方法，以便临床医生及时发现高危患者。在本研究中，我们利用武汉同济医院1479 名住院患者的临床数据（用于模型开发的群体）进行了风险评分，并利用其他两个中心的数据进行了外部验证：武汉金银潭医院的141 名住院患者（验证群体1）和深圳第三人民医院的432 名住院患者（验证群体2）。本文提出的风险评分方法是基于常规血液样本中现成的三个生物标记，能够快捷地转换为死亡概率，并且可提前12 天以上预测单个患者的死亡率，且在所有群体中准确率均超过90%。此外，Kaplan-Meier 分数表明，本方法在患者入院时即可判别低、中、高风险，并且受试者工作特征（ROC）曲线下方的面积大小（area under curve, AUC）达到0.9551。综上所述，一种简单的风险评分方法已在预测感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）患者的死亡概率任务中得到验证，同时也在多中心数据中进行了验证。

关键词： COVID-19     风险评分     死亡风险预测    

HTML PDF 收藏

基于平衡记分卡的连锁经营企业绩效评价研究

曹杰,曹国,何建敏

《中国工程科学》 2008年 第10卷 第4期   页码 90-96

摘要：

以平衡记分卡（BSC）为基础，从BSC的财务、客户、内部经营过程以及学习与成长等方面，设计了连锁经营企业的绩效考核指标体系与模糊综合评判模型，克服了传统评价体系的不足，有利于从成长的角度全面评价连锁企业绩效。

关键词： 平衡记分卡     连锁经营     绩效评价     模糊综合评价    

HTML PDF 收藏

Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

null

《医学前沿（英文）》 2017年 第11卷 第4期   页码 563-569 doi: 10.1007/s11684-017-0535-6

摘要：

The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated. This retrospective study included data collected from 1051 patients from July 2011 to June 2014. Multiple maternal baseline covariates were subjected to propensity score matching analysis, and each day 5/6 group woman was matched to one day 2/3 group woman. A systematic meta-analysis was conducted to validate the results. After matching was completed, 217 patients on the day 2/3 group were matched with those on the day 5/6 group, and no significant differences in the baseline characteristics were observed between the two groups. The cumulative pregnancy rate (57.14% vs. 53.46%, OR 1.16, 95% CI 0.79–1.70) and cumulative live birth rate (53.00% vs. 49.77%, OR 1.14, 95% CI 0.78–1.66) of day 5/6 embryo transfers were higher than those of day 2/3 embryo transfers, but this difference was not significant. The mean cycles per live birth and mean days per live birth in the day 5/6 group were significantly lower than those in the day 2/3 group. This study demonstrated that day 5/6 embryo transfer is a more cost-effective and time-efficient policy than day 2/3 embryo transfer to produce a live baby.

关键词： blastocyst     embryo transfer     cumulative pregnancy rate     cumulative live birth rate     IVF    

HTML PDF 收藏

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

《医学前沿（英文）》 2021年 第15卷 第4期   页码 621-628 doi: 10.1007/s11684-020-0738-0

摘要： Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer. This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer. Among 800 patients recruited between 2009 and 2016, the median RS was 24 (0–69), with 27.4%, 46.8%, and 25.9% patients classified into low-, intermediate-, and high-risk groups. Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival (IDFS) and distant disease-free survival (DDFS) events compared with the low-risk category (IDFS: HR= 2.450, 95% CI 1.017–5.902, = 0.046; DDFS: HR= 2.829, 95% CI 1.013–7.901, = 0.047). No significant association between RS category and overall survival (OS) was found (intermediate vs. low: HR= 1.244, 95% CI 0.292–5.297, = 0.768; high vs. low: HR= 2.933, 95% CI 0.759–11.327, = 0.119). RS, as a continuous variable, was a highly significant predictor for IDFS (HR= 1.028, 95% CI 1.010–1.047, = 0.002), DDFS (HR= 1.030, 95% CI 1.010–1.051, = 0.003), and OS (HR= 1.034, 95% CI 1.007–1.063, = 0.014). Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with N0 or N1 disease.

关键词： early breast cancer     21-gene assay     recurrence score     prognosis    

HTML PDF 收藏

Understanding and addressing the environmental risk of microplastics

《环境科学与工程前沿（英文）》 2023年 第17卷 第1期 doi: 10.1007/s11783-023-1612-5

摘要：

Over the past decades, the plastic production has been dramatically increased. Indeed, a category of small plastic particles mainly with the shapes of fragments, fibers, or spheres, called microplastics (particles smaller than 5 mm) and nanoplastics (particles smaller than 1 μm) have attracted particular attention. Because of its wide distribution in the environment and potential adverse effects to animal and human, microplastic pollution has been reported as a serious environment problem receiving increased attention in recent years. As one of the commonly detected emerging contaminants in the environment, recent evidence indicates that the concentration of microplastics show an increasing trend, for the reason that up to 12.7 million metric tons of plastic litter is released into aquatic environment from land-based sources each year. Furthermore, microplastic exposure levels of model organisms in laboratory studies are usually several orders of magnitude higher than those found in environment, and the microplastics exposure conditions are also different with those observed in the environment. Additionally, the detection of microplastics in feces indicates that they can be excreted out of the bodies of animal and human. Hence, great uncertainties might exist in microplastics exposure and health risk assessment based on current studies, which might be exaggerated. Policies reduce microplastic emission sources and hence minimize their environmental risks are determined. To promote the above policies, we must first overcome the technical obstacles of detecting microplastics in various samples.

关键词： Emerging contaminants     Microplastics     Environment risk     Health effect    

HTML PDF 收藏

Ecological Risk Management of Drinking Water Project: The Case Study of Kunming City

Ji-liang Zheng,Jun Hu,Xuan Zhou,Ching Yuen Luk

《工程管理前沿（英文）》 2015年 第2卷 第3期   页码 311-319 doi: 10.15302/J-FEM-2015045

摘要： Following rapid infrastructure development and industrialization, the problems of water pollution and water shortage have become more severe. Whether there is safe drinking water in cities has attracted wide attention. The ecological risk management of drinking water project is an important means of ensuring the safety of a drinking water source. Based on ecological risk assessment and management theories, this paper establishes an ecological risk management model and assessment system with the aim of providing theoretical guidance and scientific basis for formulating a policy on the safety and protection of drinking water sources in a city. Kunming is one of the cities plagued by severe water shortage in China. Its ecological risk management of drinking water has attracted the attention of both the local government and the public. Using Kunming as the case study, this paper conducts a comparative analysis and assessment on three major reservoirs that face ecological risks. It highlights the existing problems and gives helpful suggestions.

关键词： drinking water project     ecological risk     ecological risk assessment     risk management    

HTML PDF 收藏

我国地震预测成绩的回顾与统计

高建国

《中国工程科学》 2009年 第11卷 第6期   页码 129-131

摘要：

地震预测预报的难度大，但并非了无痕迹或不可知，我国每次较大的地震都有案例总结。统计表明，近４０ 年来，有７７ 次地震在发生前均有中期、短期甚至临震预测，不能因为汶川地震预测的失败，就全面抹杀中国的地震预报成绩，即我国的地震预测成绩是应予肯定的，汶川地震也并非是无前兆的“怪震”。

关键词： 地震     地震预测     中国近30 多年的地震预报统计    

HTML PDF 收藏

风险矩阵方法与应用述评

朱启超,匡兴华,沈永平

《中国工程科学》 2003年 第5卷 第1期   页码 89-94

摘要：

技术项目的风险管理一直深受美国国防部的重视。介绍了在美国国防采办风险管理中广泛应用的风险矩阵方法，并对其优缺点和适用性进行分析，结合我国国防预研技术项目管理的特点，提出我国开展技术性项目风险管理的思路。

关键词： 风险矩阵     风险管理     项目管理    

HTML PDF 收藏

Bioaerosol emissions variations in large-scale landfill region and their health risk impacts

《环境科学与工程前沿（英文）》 2022年 第16卷 第12期 doi: 10.1007/s11783-022-1593-9

摘要：

● The airborne bacteria in landfills were 4–50 times higher than fungi.

关键词： Microbial aerosols     Landfill sites     Health risk assessment     CALPUFF    

HTML PDF 收藏

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

《医学前沿（英文）》 2019年 第13卷 第1期   页码 32-44 doi: 10.1007/s11684-018-0678-0

摘要：

Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.

关键词： immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

HTML PDF 收藏

Epidemic obesity in children and adolescents: risk factors and prevention

Eun Young Lee, Kun-Ho Yoon

《医学前沿（英文）》 2018年 第12卷 第6期   页码 658-666 doi: 10.1007/s11684-018-0640-1

摘要： The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Furthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death. Although an imbalance between caloric intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factors are exclusively important for development of obesity among children and adolescents. In addition to genetic and biological factors, socioenvironmental factors, including family, school, community, and national policies, can play a crucial role. The complexity of risk factors for developing obesity among children and adolescents leads to difficulty in treatment for this population. Many interventional trials for childhood and adolescent obesity have been proven ineffective. Therefore, early identification and prevention is the key to control the global epidemic of obesity. Given that the proportion of overweight children and adolescents is far greater than that of obesity, an effective prevention strategy is to focus on overweight youth, who are at high risk for developing obesity. Multifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors must also be developed to prevent obesity among children and adolescents.

关键词： obesity     children     adolescents     epidemiology     risk factor     prevention    

HTML PDF 收藏

标题 作者 时间 类型 操作

Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem celltransplantation: PAH risk score

期刊论文

Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing

Ling Wang, Ying Wang, Jiong Hu, Yuqian Sun, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang

期刊论文

study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

期刊论文

rice genotypes in stress environments: fine-tuning a selection method using production and resilience score

期刊论文

COVID-19住院患者预后风险评分系统的开发和验证——一项多中心回顾性研究

袁烨, 孙川, 唐秀川, 程骋, Laurent Mombaerts, 王茂霖, 胡涛, 孙晨宇, 郭裕祺, 李秀婷, 徐卉, 任彤鑫, 肖阳, 肖亚茹, 朱红玲, 吴鸿汉, 李克之, 陈楚明, 刘映霞, 梁智超, 曹治国, 张海涛, Ioannis Ch. Paschaldis, 刘泉影, Jorge Goncalves, 钟强, 严丽

期刊论文

基于平衡记分卡的连锁经营企业绩效评价研究

曹杰,曹国,何建敏

期刊论文

Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

null

期刊论文

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

期刊论文

Understanding and addressing the environmental risk of microplastics

期刊论文

Ecological Risk Management of Drinking Water Project: The Case Study of Kunming City

Ji-liang Zheng,Jun Hu,Xuan Zhou,Ching Yuen Luk

期刊论文

我国地震预测成绩的回顾与统计

高建国

期刊论文

风险矩阵方法与应用述评

朱启超,匡兴华,沈永平

期刊论文

Bioaerosol emissions variations in large-scale landfill region and their health risk impacts

期刊论文

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

期刊论文

Epidemic obesity in children and adolescents: risk factors and prevention

Eun Young Lee, Kun-Ho Yoon

期刊论文